The Breakthrough Challenge
We raise funds to support breakthroughs in cancer research at Penn Medicine's Abramson Cancer Center (ACC). Founded in 2013, the Breakthrough Challenge unites patients, researchers, their families, and friends for a scenic and inspiring bike ride through Eastern PA's beautiful Oley Valley. To date, the Breakthrough Challenge has donated $2,825,000 to the ACC, funding 63 research projects. 100% of all participant-raised dollars are donated directly to cancer research.

Our 2025 Fundraising Goal
Match Challenge Week: July 14th - July 20th
Donations received will be matched by the Zent Family Foundation until the match funding is exhausted.
The match challenge goal has been met!
$25,008 raised in 15 hours and 40 minutes!
Thank you!

$72,077
Raised of $300,000
Breakthroughs in Action

Thank You To Our Fundraisers!
Top Individuals
View AllLou Starzl
$8,400.00 raised of $10,000.00
Bo Ebby
$6,150.00 raised of $10,000.00
William Wilson
$5,250.00 raised of $1,000.00
Drew Costello
$5,050.00 raised of $500.00
David Wellborn
$2,825.00 raised of $6,000.00
Top Teams
View AllKeystone State Ride
$25,709.53 raised of $30,000.00
Team BC
$8,475.00 raised of $20,000.00
DTeam
$6,100.00 raised of $20,000.00
Mission Melanoma
$5,850.00 raised of $0.00
Beam of Life
$3,257.38 raised of $10,000.00
Donate To an Indvidual or a Team
Donate NowJoin Us to Make a Difference!
