The Breakthrough Challenge
We raise funds to support breakthroughs in cancer research at Penn Medicine's Abramson Cancer Center (ACC). Founded in 2013, the Breakthrough Challenge unites patients, researchers, their families, and friends for a scenic and inspiring bike ride through Eastern PA's beautiful Oley Valley. To date, the Breakthrough Challenge has donated over $3.1 million dollars to the ACC, funding 74 research projects. 100% of all participant-raised dollars are donated directly to cancer research.
Our 2026 Fundraising Goal
$254,236
Raised of $300,000
Team Building Promotion On Now!
Sponsored by the Smilow Foundation
Earn a $150 donation credit for your referrals
$800 remaining as of 10:30AM September 9th, 2026
Our 2025 Event Raised $350K!
Our Leaderboards
Top Fundraisers
Top Individuals (250)
View AllBo Ebby
$16,900.00 raised of $20,000.00
David Wellborn
$16,050.00 raised of $20,000.00
Tina Wilson
$15,114.00 raised of $1,000.00
Top Teams (26)
View AllKeystone State Ride
$75,721.60 raised of $80,000.00
Team BC
$47,375.10 raised of $50,000.00
Team Zayde
$24,702.00 raised of $18,000.00
Mission Melanoma
$18,386.80 raised of $10,000.00
Team Krieger
$16,026.00 raised of $20,000.00
Donate To an Indvidual or a Team
Donate NowBreakthroughs in Action
Join Us to Make a Difference!
