Registration is Now Open!

We raise funds to support breakthroughs in cancer research at Penn Medicine's Abramson Cancer Center (ACC). Founded in 2013, the Breakthrough Challenge unites patients, researchers, their families, and friends for a scenic and inspiring bike ride through Eastern PA's beautiful Oley Valley. To date, the Breakthrough Challenge has donated over $3.1 million dollars to the ACC, funding 63 research projects. 100% of all participant-raised dollars are donated directly to cancer research.